منابع مشابه
Vitamin B12 and protein biosynthesis. VI. Relation of vitamin B12 to amino acid activation.
It has been reported (l-5) from this laboratory that vitamin Blz functions in vivo and in vitro in the incorporation of amino acids into protein. There was observed a reduction in the incorporation of amino acids into protein in vitamin Brz-deficient pigs and rats in vivo as compared to normal animals (4). Similar reduction in the incorporation of amino acids was observed upon incubation of liv...
متن کاملVitamin B12 and protein metabolism.
Fat in the diet of rats. 8 39 carbon dioxide plus soya-bean oil (ratio 2: I) grew poorly, and all died during the first half of the experimental period. 4. The animals fed on a mixture of PT 006 or PT 006 plus distillate-soya-bean oil (ratio 2: I ) grew throughout the whole experimental period (36 weeks), although significantly more slowly than the controls. No neoplastic tissue was found at au...
متن کاملCrystallization and preliminary structure analysis of CobE, an essential protein of cobalamin (vitamin B12) biosynthesis.
CobE, a protein implicated in vitamin B12 biosynthesis, from Pseudomonas aeruginosa has been overexpressed in Escherichia coli, purified and crystallized using hanging-drop vapour diffusion. The crystals belong to the primitive orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 31.86, b = 41.07, c = 87.41 A. The diffraction extends to a resolution of 1.9 A. There is one molec...
متن کاملAnaerobic biosynthesis of the lower ligand of vitamin B12.
Vitamin B12 (cobalamin) is required by humans and other organisms for diverse metabolic processes, although only a subset of prokaryotes is capable of synthesizing B12 and other cobamide cofactors. The complete aerobic and anaerobic pathways for the de novo biosynthesis of B12 are known, with the exception of the steps leading to the anaerobic biosynthesis of the lower ligand, 5,6-dimethylbenzi...
متن کاملOral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency.
BACKGROUND Vitamin B12 deficiency is common, and the incidence increases with age. Most people with vitamin B12 deficiency are treated in primary care with intramuscular (IM) vitamin B12. Doctors may not be prescribing oral vitamin B12 formulations because they may be unaware of this option or have concerns regarding its effectiveness. OBJECTIVES To assess the effects of oral vitamin B12 vers...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1958
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64715-5